Strain Differences in the Neural , Behavioral and Molecular Correlates of Sweet 1 and Salty Taste in Naïve , Ethanol - and Sucrose - exposed P and NP Rats 2

نویسندگان

  • Jamison Coleman
  • Ashley Williams
  • Tam-Hao T. Phan
  • Shobha Mummalaneni
  • Pamela Melone
  • ZuoJun Ren
  • Huiping Zhou
  • Sunila Mahavadi
  • Karnam S. Murthy
  • Tadayoshi Katsumata
  • John A. DeSimone
  • Vijay Lyall
چکیده

6 Department of Physiology and Biophysics, Department of Microbiology and 7 Immunology, Virginia Commonwealth University, Richmond, VA 23298 USA and Kirin 8 Kyowa Foods Co. LTD, Ibaraki, Japan 300-0398. 9 10 RUNNING TITLE: Sweet and salty taste responses in P and NP Rats 11 12 Corresponding Author: Dr. Vijay Lyall 13 Associate Professor 14 Department of Physiology and Biophysics 15 Virginia Commonwealth University 16 Molecular Medical Research Building (MMRB) #5052 17 1220 East Broad Street, Richmond, VA 23219 18 Tel: (804) 828-9759 19 Fax: (804) 827-0947 20 E-mail: [email protected] 21 22 Articles in PresS. J Neurophysiol (August 17, 2011). doi:10.1152/jn.00196.2010

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Strain differences in the neural, behavioral, and molecular correlates of sweet and salty taste in naive, ethanol- and sucrose-exposed P and NP rats.

Strain differences between naive, sucrose- and ethanol-exposed alcohol-preferring (P) and alcohol-nonpreferring (NP) rats were investigated in their consumption of ethanol, sucrose, and NaCl; chorda tympani (CT) nerve responses to sweet and salty stimuli; and gene expression in the anterior tongue of T1R3 and TRPV1/TRPV1t. Preference for 5% ethanol and 10% sucrose, CT responses to sweet stimuli...

متن کامل

Differential neural representation of oral ethanol by central taste-sensitive neurons in ethanol-preferring and genetically heterogeneous rats.

In randomly bred rats, orally applied ethanol stimulates neural substrates for appetitive sweet taste. To study associations between ethanol's oral sensory characteristics and genetically mediated ethanol preference, we made electrophysiological recordings of oral responses (spike density) by taste-sensitive nucleus tractus solitarii neurons in anesthetized selectively bred ethanol-preferring (...

متن کامل

Drinking of flavored solutions by high preferring (WHP) and low preferring (WLP) alcohol-drinking rats.

BACKGROUND Selective breeding alcohol-preferring (P) and alcohol-nonpreferring (NP) rats showed a strong preference for the sucrose solutions, whereas P rats intake greater amounts than NP rats. The aim of this study was the estimation of selectively bred ethanol-preferring (WHP - Warsaw High Preferring) and ethanol-nonpreferring (WLP - Warsaw Low Preferring) rats for their preference for vario...

متن کامل

T1r3 taste receptor involvement in gustatory neural responses to ethanol and oral ethanol preference.

Elevated alcohol consumption is associated with enhanced preference for sweet substances across species and may be mediated by oral alcohol-induced activation of neurobiological substrates for sweet taste. Here, we directly examined the contribution of the T1r3 receptor protein, important for sweet taste detection in mammals, to ethanol intake and preference and the neural processing of ethanol...

متن کامل

Gastric bypass surgery alters behavioral and neural taste functions for sweet taste in obese rats.

Roux-en-Y gastric bypass surgery (GBS) is the most effective treatment for morbid obesity. GBS is a restrictive malabsorptive procedure, but many patients also report altered taste preferences. This study investigated the effects of GBS or a sham operation (SH) on body weight, glucose tolerance, and behavioral and neuronal taste functions in the obese Otsuka Long-Evans Tokushima Fatty (OLETF) r...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011